A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.

Additional Information

Synonyms	(4,5,6,7,15,17)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid -lactone Methyl Ester; CCRIS 5723, NSC-309909
Product #	N-2365
CAS #	25990-37-8
Chemical Name	(4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
Formula	C27H30O7
MW	466.52
Appearance	White to off-white Solid
Purity	98% by TLC
Solubility	DMSO (50 mM)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis

Additional Information

MDL Number	MFCD01735386
ChemACX	X4346989-2
InChI	InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3
SMILES	CC1=C2C(CC1c3ccoc3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C