A potent, selective BCR-ABL inhibitor that fits into the ATP- of the BCR-ABL protein with higher affinity than imatinib (Cat. No. 1625-100, 1000). Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC< 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants.
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