The major flavanone found in grapefruit. Acts as an antioxidant, free radical scavenger and carbohydrate metabolism promoter. Shows cytotoxicity in various human cell lines and promotes apoptosis in rat C6 glioma model. Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet. Also lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed with a high-cholesterol diet.

Additional Information

Synonyms	5,7,4'-Trihydroxyflavanone; 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; NGEN
Product #	N-2361
CAS #	480-41-1
Chemical Name	5,7,4'-Trihydroxyflavanone; 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; NGEN
Formula	C15H12O5
MW	272.26
Appearance	Brown Solid
Purity	98% by TLC
Solubility	DMSO or EtOH (50 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Hepatitis C virus particles demonstrate that Naringenin can inhibit the virus via a PPAR-mediated mechanism by inhibiting the long term assembly of the virus

Additional Information

MDL Number	MFCD00006844
ChemACX	X5334626-0
InChI	InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1
SMILES	c1cc(ccc1[C@@H]2CC(=O)c3c(cc(cc3O2)O)O)O