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Temsirolimus

品牌：AG Scientific

货号：

规格：5 mg

货期：

应用：

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CAS:162635-04-3Formula:C56H87NO16MW:1030.29Appearance:Whitetooff-whiteSolidPurity:99%

商品详情参考文献相关资料

mTOR inhibitor with anti-cancer activity. Temsirolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective acylation of the 42-hydroxy group with a protected bis(dihydromethyl)propionic acid, followed by deprotection. It has anti-angiogenic effects which may contribute to the antitumor activity of temsirolimus observed in breast cancer. Temsirolimus shows synergistic in vivo anti-myeloma effects in combination with dexamethasone in a xenograft model. Temsirolimus is extensively cited in the literature with over 700 citations.

Additional Information

Synonyms	CCI-779,Torisel
Product #	T-2453
CAS #	162635-04-3
Chemical Name	42-[3-HYDROXY-2-(HYDROXYMETHYL)-2-METHYLPROPANOATE]-RAPAMYCIN
Formula	C₅₆H₈₇NO₁₆
MW	1030.29
Appearance	White to off-white Solid
Purity	99%
Solubility	Soluble in chloroform, methanol, DMSO (75 mg/ml at 25 °C), water (1 mg/ml at 25 °C), and ethanol (75 mg/ml at 25 °C)
Melting Point	>270 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	mTOR inhibitor with anti-cancer activity, Temsirolimus (CCI-779) is an intravenous drug for the treatment of renal cell carcinoma (RCC)

Additional Information

MDL Number	MFCD00934421
ChemACX	X1608605-0
InChI	InChI=1S/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67,73-41)51(63)52(64)57-24-16-15-19-42(57)53(65)71-46(30-43(60)35(3)26-38(6)49(62)50(70-11)48(61)37(5)25-33)36(4)27-40-21-23-44(47(28-40)69-10)72-54(66)55(8,31-58)32-59/h12-14,17-18,26,33,35-37,39-42,44-47,49-50,58-59,62,67H,15-16,19-25,27-32H2,1-11H3/b14-12+,17-13+,34-18+,38-26+/t33-,35-,36-,37-,39-,40+,41+,42+,44-,45+,46+,47-,49-,50+,56-/m1/s1
SMILES	C[C@@H]1CCC2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC

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