A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Refer to B1183 for Bafilomycin A1. Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney. Bafilomycin B1 has demonstrated that 4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation. Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy.
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