*Please inquire the availability for this product. Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumor activity in vivo against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of leptomycin B, an inhibitor of nuclear export of proteins.

Additional Information

Synonyms	5-Demethylleptomycin A, KR 2827A
Product #	A-2599
CAS #	111278-01-4
Chemical Name	(2E,10E,12E,16Z,18E)-6-HYDROXY-3,5,7,9,11,15,17-HEPTAMETHYL-8-OXO-19-(6-OXO-3,6-DIHYDRO-2H-PYRAN-2-YL)-2,10,12,16,18-NONADECAPENTAENOIC ACID
Formula	C31H44O6
MW	512.7
Appearance	Pale yellow film
Purity	>95% by HPLC
Solubility	Soluble in methanol, and ethanol Insoluble in DMSO
Storage Temp	-20° C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of nuclear export of proteins it shows antitumor activity

Additional Information

MDL Number	MFCD09752704
InChI	InChI=1S/C31H44O6/c1-20(16-22(3)14-15-27-12-9-13-29(34)37-27)10-8-11-21(2)17-24(5)30(35)26(7)31(36)25(6)18-23(4)19-28(32)33/h8-9,11,13-17,19-20,24-27,31,36H,10,12,18H2,1-7H3,(H,32,33)/b11-8+,15-14+,21-17+,22-16-,23-19+
SMILES	O=C\1OC(/C=C/C(=C\C(C)C\C=C\C(=C\C(C(=O)C(C)C(O)C(CC(=C\C(=O)O)\C)C)C)C)C)C/C=C/1