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MIF-Antagonist, ISO-1
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MIF-Antagonist, ISO-1
品牌：AG Scientific
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规格：5 mg
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CAS:478336-92-4Formula:C12H13NO4MW:235.24Appearance:Off-WhiteSolidPurity:98%byHPLC
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Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.

Additional Information

Synonyms(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Product #M-2379
CAS #478336-92-4
Chemical Name(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
FormulaC12H13NO4
MW235.24
AppearanceOff-White Solid
Purity98% by HPLC
SolubilitySoluble in DMSO (~25 mg/ml)
Melting Point133.69 °C
Storage Temp-20°C
Therapeutic AreaEndocrinological Disorders
UseMIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic

Additional Information

MDL NumberMFCD22376813
ChemACXX4983373-6
InChIInChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
SMILESCOC(=O)CC1CC(=NO1)c2ccc(cc2)O
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