A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase-, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

Additional Information

Synonyms	[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)- 3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid; Fludara
Product #	F-2329
CAS #	75607-67-9
Chemical Name	[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)- 3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid; Fludara
Formula	C10H13FN5O7P
MW	365.21
Appearance	White Solid
Purity	98%
Solubility	Soluble in DMSO or H2O (5 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies

Additional Information

MDL Number	MFCD00866418
ChemACX	X1014395-4
InChI	InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
SMILES	c1nc2c(nc(nc2n1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)F)N