Elastatinal is an elastase inhibitor and has exhibited the ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro. Elastatinal is a tetrapeptide derivative with an aldehyde group which is essential for inhibitory activity. Additionally, it has no effect on DNA repair and UV-induced sister chromatid exchanges, and inhibits the cleavages found at Ala-Ala bonds in peptides that represent the capsid/nucleocapsid site. Elastatinal is an inhibitor of Neutrophil Elastase. In pancreatic tumors Elastatinal has demonstrated the ability to reduce the rate of degradation of endostatin, an angiogenesis inhibitor.

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Additional Information