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E-64D

品牌：AG Scientific

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规格：1 mg

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CAS:88321-09-9Formula:C17H30N2O5MW:342.433Appearance:Solid

商品详情参考文献相关资料

An irreversible, highly selective cysteine protease inhibitor and cell permeable analog of E-64D. Specifically E-64D is an irreversible cathepsin L and B inhibitor.

Most recently e-64D, a pan-cysteine cathepsin inhibitor plays an important role in Ebola virus (EBOV) progression by preventing entry by filoviruses, especially EBOV. E-64d has been shown to lead to the accumulation of CTFs and AICD with no change in gamma and beta secretase activities. Additionally, utilizing E-64d has shown results in accumulation of autophagic bodies inside vacuoles in Arabidopsis root cells.

Additional Information

Synonyms	E-64D, E64d
Product #	E-2401
CAS #	88321-09-9
Formula	C₁₇ H₃₀ N₂ O₅
MW	342.433
Appearance	Solid
Solubility	Soluble in ethanol (>10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml), and 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml). Insoluble in water
Therapeutic Area	Neurological Disorders
Use	The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease by inhibiting cathepsin B, but not BACE1, β-secretase activity

Additional Information

MDL Number	MFCD00132883
ChemACX	X1061801-0
InChI	InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
SMILES	CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

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