Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells.

Additional Information

Synonyms	KRX-0402
Product #	P-2392
CAS #	157716-52-4
Chemical Name	1,1-DIMETHYLPIPERIDINIUM-4-YL OCTADECYL PHOSPHATE
Formula	C25H53NO4P
MW	462.66
Appearance	White to off-white Solid
Purity	99%
Solubility	Soluble in H2O (10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An alkylphospholipid which inhibits Akt activation and the anti-apoptotic MAPK pathway used for variety of cancers

Additional Information

MDL Number	MFCD00927554
ChemACX	X1600392-6
InChI	InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3/p+1
SMILES	CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](CC1)(C)C