Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC = 180 nM)

Additional Information

Synonyms	Nec-1
Product #	N-1227
CAS #	4311-88-0
Chemical Name	Methythiohydantoin-DL-tryptophan
Formula	C13H13N3OS
MW	259.332
Appearance	Yellow Solid
Purity	98 (TLC)
Solubility	Soluble in DMSO (25mg/ml) or EtOH(6mg/ml)
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	An inhibitor of the necroptosis cell death pathway used necroptosis in ischemic brain injury

Additional Information

MDL Number	MFCD00056916
ChemACX	X1093197-8
InChI	InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
SMILES	CN1C(=O)C(NC1=S)Cc2c[nH]c3c2cccc3