A derivative of the macrolide Rapamycin (Cat. No. 1568-5, 50) that acts as an immunosuppressant, mTOR inhibitor and anticancer agent. It targets the raptor mammalian target of rapamycin (mTORC1).

Additional Information

Synonyms	RAD-001
Product #	E-2309
CAS #	159351-69-6
Chemical Name	40-O-(2-HYDROXYETHYL)-RAPAMYCIN
Formula	C53H83NO14
MW	958.22
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	DMSO
Melting Point	110-115 °C
Storage Temp	-20°C
Therapeutic Area	Autoimmune Diseases
Use	It is used as an immunosuppressant to prevent rejection of organ transplants

Additional Information

MDL Number	MFCD00929329
ChemACX	X1495513-8
InChI	InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35+,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC