Cell-permeable. A reversible, noncompetitive inhibitor of dynamin that interferes in vitro with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition.

Additional Information

Synonyms	3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide
Product #	D-2298
CAS #	304448-55-3
Chemical Name	3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide
Formula	C18H14N2O4
Appearance	Off-White Solid
Purity	98% by NMR
Solubility	DMSO (10 mg/ml) or EtOH (1 mg/ml)
Melting Point	251.04 °C
Storage Temp	-20°C
Use	Cell permeable dynamin inhibitor, that blocks endocytosis

Additional Information

MDL Number	MFCD00292551
ChemACX	X1598587-2
InChI	InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
SMILES	c1ccc2cc(c(cc2c1)C(=O)N/N=C/c3ccc(c(c3)O)O)O