*Please inquire the availability for this product. LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

Additional Information

Synonyms	C292, L 783278, 5Z-7-Oxozeaenol
Product #	L-2559
CAS #	253863-19-3
Formula	C19H22O7
MW	362.4
Appearance	White solid
Purity	>99% by HPLC
Solubility	Soluble in ethanol (10 mM), methanol, DMF, DMSO (25 mM), acetone, ethyl acetate, and water (limited solubility ) Insoluble in n-hexane
Storage Temp	-20°C
Therapeutic Area	Inflammatory Diseases
Use	LL Z1640-2 effectively prevents inflammation

Additional Information

MDL Number	MFCD12912700
InChI	InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
SMILES	C[C@H]1C/C=C\C(=O)[C@H]([C@H](C/C=C/c2cc(cc(c2C(=O)O1)O)OC)O)O