Cell-permeable. Maintains the undifferentiated state of embrryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatases PP2A, it prevents -catenin from switching coactivator usage from CBP to p300. The increase in -cateinin/CBP mediated transcription at the expense ofcateinin/CBP mediated transcription helps to maintain the murine stem cell pluripotency.

Additional Information

Synonyms	2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3, 3-dimethyl-1 (2H)-isoquinolinylidene)-acetamide
Product #	I-1332
CAS #	331001-62-8
Chemical Name	2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3, 3-dimethyl-1 (2H)-isoquinolinylidene)-acetamide
Formula	C21H22N4O2
MW	362.42
Appearance	Orange Solid
Purity	95% by HPLC
Solubility	DMSO
Storage Temp	Keep cool and dry. Store at +4°C
Use	IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling

Additional Information

MDL Number	MFCD00354369
ChemACX	X1835808-2
InChI	InChI=1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,23H,12H2,1-3H3,(H2,22,27)/b19-18+,25-24+
SMILES	CC(=O)c1ccc(cc1)/N=N/C(=C/2c3ccccc3CC(N2)(C)C)/C(=O)N