GSK-J4, JMJ H3K27 Demethylase inhibitor (Cell Permeable) |产品详情|进口试剂采购网

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GSK-J4, JMJ H3K27 Demethylase inhibitor (Cell Permeable)

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GSK-J4, JMJ H3K27 Demethylase inhibitor (Cell Permeable)

品牌：AG Scientific

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规格：25 mg

货期：

应用：

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CAS:1373423-53-0Formula:C24H27N5O2MW:417.48Appearance:YellowwaxysolidPurity:99%byTLCNMR(Conforms)

商品详情参考文献相关资料

GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393). GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

Additional Information

Synonyms	Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
Product #	G-2643
CAS #	1373423-53-0
Chemical Name	N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Formula	C₂₄H₂₇N₅O₂
MW	417.48
Appearance	Yellow waxy solid
Purity	99% by TLC NMR (Conforms)
Solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Storage Temp	-20°