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GANT58

品牌：AG Scientific

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规格：5 mg

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CAS:64048-12-0Formula:C24H16N4SMW:392.48Appearance:YellowSolidPurity:98%byHPLC

商品详情参考文献相关资料

Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC~ 5 M in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

Additional Information

Synonyms	2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
Product #	G-2333
CAS #	64048-12-0
Chemical Name	2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
Formula	C₂₄H₁₆N₄S
MW	392.48
Appearance	Yellow Solid
Purity	98% by HPLC
Solubility	DMSO (25 mM) or Ethanol (25 mM)
Melting Point	256-258 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells

Additional Information

MDL Number	MFCD01103196
ChemACX	X1197193-8
InChI	InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
SMILES	c1cnccc1c2c(c(sc2c3ccncc3)c4ccncc4)c5ccncc5

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