Cell-permeable. A potent, selective, reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki=109 nM in the presence of ATP and no AMP). Displays no significant inhibition of JAK3, PKA, PKCθ, SYK and ZAPK. Suppresses food intake in mice and inhibits the effects of AICAR and metformin.Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells. In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent pathway.
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