Potent, selective inhibitor of Protein Kinase C isozymes, PKC I(IC50=4.7 nM) and PKC II (IC50=5.9 nM)..Human Biliverdin Reductase, a Previously Unknown Activator of Protein Kinase C II.Role of p90 Ribosomal S6 Kinase (p90RSK) in Reactive Oxygen Species and Protein Kinase C (PKC-)-mediated Cardiac Troponin I Phosphorylation.PKC- is upstream and PKC- is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium.Vascular Endothelial Growth Factor Induces MEF2C and MEF2-Dependent Activity in Endothelial Cells.Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

Additional Information

Synonyms	Ruboxistaurin . hydrochloride
Product #	L-1011
CAS #	169939-93-9
Chemical Name	(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiaza-cyclohexadecene-1,3(2H)-dione. hydrochloride
Formula	C28H28N4O3.HCl
MW	504.5
Appearance	Red to Orange Solid
Purity	98%
Solubility	Soluble in DMSO, Slightly soluble in 100% ethanol or water
Storage Temp	+4°C
Therapeutic Area	Ophthalmological Disorders
Use	LY333531 is a potent inhibitor of protein kinase Cß use in diabetic. LY333531 improves blood flow and leukocyte entrapment in the retina

Additional Information

MDL Number	MFCD00940226
ChemACX	X1704593-1
InChI	InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
SMILES	CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl