A Stat3 phosphorylation inhibitor. LLL12 inhibits STAT3 phosphorylation (Tyr705) and STAT3 activities and down-regulates STAT3 downstream targets; inhibits proliferation, colony formation, and cell migration and induces apoptosis in various human breast and pancreatic cancer cells as well as in glioblastoma cells. LLL12 has minimal apoptotic effects on normal human cells.

Additional Information

Synonyms	5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
Product #	L-2376
Chemical Name	5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
Formula	C14H9NO5S
MW	303.29
Appearance	Lyophilized Solid
Purity	95% by HNMR
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A Stat3 phosphorylation inhibitor use in cancer

Additional Information

InChI	InChI=1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20)
SMILES	c1cc2c(c(c1)O)C(=O)c3cccc(c3C2=O)S(=O)(=O)N