The tetramic acid, Equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against human immunodeficiency virus type 1 (HIV-1) integrasein vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core. Newly isolated microbial agent.
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