Biological Activity:Cyclosporin A is an inhibitor of the mitochondrial permeability transition pore (MPTP). It protects mouse bone marrow and human cord blood HSCs from EPHOSS during collection in air, resulting in increased recovery of transplantable HSCs. It was used as immunosuppressant and could inhibit phosphatase activity of calcineurin (IC50 ~5 nM).How to Use: In vitro: Cyclosporin A was used at 50 µg/ml in the collection of cord blood process.In vivo: n/a Reference:
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