Biological Activity:Azidothymidine (AZT) is a selective, orally bioavailable and brain penetrant reverse transcriptase inhibitor. It has 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. It can suppress HIV-1 replication and enhance cell viability in a HIV-1 infected T cell line. It can also suppress growth of a multiple myeloma (MM) cell line and reduces the growth of MM tumor xenografts in mice. In recent studies, AZT can enhance CRISPR-mediated sequence-specific gene knockout via NHEJ in human induced pluripotent stem cells (iPSCs) and other cell types. How to Use:In vitro: Azidothymidine (AZT) was used at 5-30 µM final concentration in various in vitro assays.In vivo: Azidothymidine (AZT) was dosed to mice at 10-50 mg/kg orally once per day. Reference:
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