WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC₅₀ ~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.

How to Use:

• In vitro:  WAY-316606 was used at 1-10 µM final concentration in various in vitro assays.
• In vivo:  n/a

Reference:

• 1. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. (2009) Bone. 44(6):1063-8.
• 2. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (2009) J Med Chem. 52(1):105-16.
• 3. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. (2010) Bioorg Med Chem. 18(1):190-201.

Products are for research use only. Not for human use.