Biological Activity:

Daidzein-2c is a potent synthetic daidzein analog, has osteogenic induction potentials on human Mesenchymal Stem Cells (MSC). Human bone marrow derived mesenchymal stem cells from three different donors were treated with Daidzein-2c and shown to exhibit enhanced osteogenesis when compared to daidzein or estrogen treatment. The enhanced osteogenic induction by Daidzein-2c resulted in increased osterix (Sp7), alkaline phosphatase (ALP), osteopontin (OPN), and insulin-like growth factor 1 (IGF-1), which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells. It serves as a useful chemical tool to further validate and develop novel treatments of osteoporosis via promoting bone formation.

How to Use:

• In vitro:  Daidzein-2c was used at 1 µM final concentration in various in vitro assays.
• In vivo: N/A

Reference:

• 1. Amy L, et al. Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells. (2014) ACS Med. Chem. Lett., In press.

Products are for research use only. Not for human use.