肾小球内皮细胞是一种分化的微血管细胞,参与调节肾小球的滤过。它们形成滤过屏障的内侧部分,且参与肾小球的病变。肾小球内皮细胞持续分泌生物活性分子,并可被炎症和血栓形成所上调。严重肾小球缺陷导致的内皮细胞损伤,可抑制局部血管生成和损伤部位的肾小球硬化。肾小球内皮细胞的损伤可影响肾小球系膜细胞和上皮细胞,并导致肾脏疾病的进展[4]。由于肾小球内皮细胞在培养、克隆和增殖方面的困难,使得该细胞的生物学特性仍不为人所知。
Sciencell研究实验室的人肾小球内皮细胞是从人的肾中分离得到的,纯化后冻存,冰冻运输。每管细胞密度*过5×10^5/ml。该细胞可通过 vWF/Factor VIII 和CD31 (PECAM)特异性抗体的免疫荧光及体外微导管结构的形成进行鉴定。本细胞经检测不含HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌。如采用ScienCell 实验室特制的培养基,可保证此细胞15倍增殖。
推荐培养基:内皮细胞培养基?(ECM, Cat. #1001)
货号
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4000
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产地
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美国
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缩写
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HRGEC
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规格
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5 x 10^5/1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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1.) Guo W, Ding J, Zhang A, Dai W, Liu S, Diao Z, Wang L, Han X, Liu W. (2014) "The Inhibitory Effect of Quercetin on Asymmetric Dimethylarginine-Induced Apoptosis Is Mediated by the Endoplasmic Reticulum Stress Pathway in Glomerular Endothelial Cells."?Int j mol sci. 15: 484-503.
2.) Park SW, Kim M, Chen SW, Brown KM, D'Agati VD, Lee HT. (2010) "Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation."?Lab Invest. 90: 1209-24.
3.) Zupancic ML, Frieman M, Smith D, Alvarez RA, Cummings RD, Cormack BP. (2008) "Glycan microarray analysis of Candida glabrata adhesin ligand specificity."?Mol Microbiol. 68: 547-59.?
4.) Advani A, Kelly DJ, Advani SL, Cox AJ, Thai K, Zhang Y, White KE, Gow RM, Marshall SM, Steer BM, Marsden PA, Rakoczy PE, Gilbert RE. (2007) "Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions."?Proc Natl Acad Sci USA. 104: 14448-53.
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