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人肺动脉平滑肌细胞 HPASMC
品牌:ScienCell Research Laboratories Inc
货号:3110
规格:
货期:

人肺动脉平滑肌细胞 HPASMC

商品详情 参考文献 相关资料
平滑肌细胞是多数重要动脉疾病的靶细胞。血管SMC的生长潜力是原发血管病发展中至关重要的异常因素。*新研究表明SMC表达的钙通道,其表面表达的ICAM-1和VCAM-1,均参与了血管壁的炎症反应,并与血管疾病的进展和稳定有关。慢性肺组织缺氧能造成血管重塑,肺动脉平滑肌增生,*终导致肺动脉高压。人血管平滑肌的体外培养可作为血管研究模型,为血管疾病的治疗和药理学研究提供信息,发挥重要作用。
人肺动脉平滑肌细胞提取于人肺动脉组织,二代冻存。每管含有细胞数>5×10^5 cells/ml,此细胞通过对alpha-SMA和Desmin免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。

推荐培养基:平滑肌细胞培养基 (SMCM, Cat. #1101)
货号 3110
产地 美国
缩写 HPASMC
规格 5 x 10^5 /1ml
用途 科研
储存 液氮
运输 干冰
1.) Wang HL, Peng LP, Chen WJ, Tang SH, Sun BZ, Wang CL, Huang R, Xu ZJ, Lei WF. (2014) 'HMGB1 enhances smooth muscle cell proliferation and migration in pulmonary artery remodeling.'

2.) Ibrahim YF, Wong CM, Pavlickova L, Liu L, Trasar L, Bansal G, Suzuki YJ. (2014) 'Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug?Induced Cell Killing.'

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4.) Ibrahim YF, Wong CM, Pavlickova L, Liu L, Trasar L, Bansal G, Suzuki YJ. (2014) "Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug?Induced Cell Killing." J Am Heart Assoc. 3: e000520.

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7.) Zha WJ, Qian Y, Shen Y, Du Q, Chen FF, Wu ZZ, Li X, Huang M. (2013) "Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-?B."Evid Based Complement Alternat Med. 2013:767689.

8.) Wang G, Zhang Z, Xu Z, Yin H, Bai L, Ma Z, Decoster MA, Qian G, Wu G. (2010) "Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia." Biochim Biophys Acta. 1803: 1359-67.

9.) de Frutos S, Nitta CH, Caldwell E, Friedman J, Gonz?lez Bosc LV. (2009) "Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR." Am J Physiol Lung Cell Mol Physiol. 297: L475-86.

10.) de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, Rabinovitch M. (2009) "Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways." J Cell Biol.184: 83-99.

11.) Wang Z, Yuan Z, Jin L. (2008) "Gene delivery into hepatocytes with the preS/liposome/DNA system." Biotechnol J. 3: 1286-95.

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