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Anti-FBXO11 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-FBXO11 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-FBXO11 Antibody See all FBXO11 primary antibodies
Description:	Rabbit polyclonal antibody to FBXO11
Specificity:	The antibody detects endogenous level of total FBXO11 antibody.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human FBXO11.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Tissue Specificity:	Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Cellular Location:	Nucleus. Chromosome.
Database Links:	Entrez Gene: 80204 Human Entrez Gene: 225055 Mouse Entrez Gene: 301674 Rat Omim: 607871 Human SwissProt: Q86XK2 Human SwissProt: Q7TPD1 Mouse SwissProt: Q7TSL3 Rat Unigene: 352677 Human Unigene: 386857 Mouse Unigene: 36585 Rat
Synonyms:	F box only protein 11 Antibody F box protein 11 Antibody F-box only protein 11 Antibody FBX11 Antibody FBX11_HUMAN Antibody FBXO11 Antibody PRMT9 Antibody Protein arginine N methyltransferase 9 Antibody Ubiquitin protein ligase E3 component n recognin 6 Antibody UBR6 Antibody UG063H01 Antibody VIT 1 Antibody VIT-1 Antibody VIT1 Antibody Vitiligo associated protein 1 Antibody Vitiligo associated protein VIT 1 Antibody Vitiligo-associated protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.