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Anti-FBXL5 Antibody

品牌：Antibodies

货号：

规格：100µl

货期：

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Anti-FBXL5 Antibody

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Name:	Anti-FBXL5 Antibody See all FBXL5 primary antibodies
Description:	Rabbit polyclonal antibody to FBXL5
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Rabbit polyclonal FBXL5 (1) antibody was raised against a recombinated human FBXL5 protein 510-691aa (BC030656).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified
Concentration:	1.0mg / ml
Formulation:	PBS, pH 7.4 with 0.02% Sodium Azide
Storage:	This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Function:	Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity).
Post-Translational Modification:	Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor (By similarity).
Cellular Location:	Cytoplasm > Perinuclear region.
Database Links:	Entrez Gene: 26234?Human Entrez Gene: 242960?Mouse Entrez Gene: 305424?Rat Omim: 605655?Human SwissProt: Q9UKA1?Human SwissProt: Q8C2S5?Mouse Unigene: 643433?Human Unigene: 714386?Human Unigene: 25794?Mouse
Synonyms:	F box and leucine rich repeat protein 5 Antibody F box protein FBL5 Antibody F box/LRR repeat protein 5 Antibody F-box and leucine-rich repeat protein 5 Antibody F-box protein FBL4/FBL5 Antibody F-box/LRR-repeat protein 5 Antibody FBL4 Antibody FBL5 Antibody FBXL5 Antibody FBXL5_HUMAN Antibody FLR1 Antibody p45SKP2 like protein Antibody p45SKP2-like protein Antibody
Information:	Target information shown above is from the UniProt Consortium.