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Anti-ERAP1 (K467) Antibody

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规格：50µl

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Anti-ERAP1 (K467) Antibody

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Overview

Name:	Anti-ERAP1 (K467) Antibody See all ERAP1 primary antibodies
Description:	Rabbit polyclonal antibody to ERAP1 (K467)
Specificity:	ERAP1 (K467) pAb detects endogenous levels of ERAP1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 435-489 of Human ERAP1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 110 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the peptidase M1 family.
Post-Translational Modification:	N-glycosylated.
Cellular Location:	Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 51752?Human Entrez Gene: 80898?Mouse Entrez Gene: 80897?Rat Omim: 606832?Human SwissProt: Q9NZ08?Human SwissProt: Q9EQH2?Mouse SwissProt: Q9JJ22?Rat Unigene: 716426?Human Unigene: 83526?Mouse Unigene: 22516?Rat
Synonyms:	A LAP Antibody A-LAP Antibody Adipocyte derived leucine aminopeptidase Antibody Adipocyte-derived leucine aminopeptidase Antibody ALAP Antibody Aminopeptidase PILS Antibody Aminopeptidase regulator of TNFR1 shedding Antibody APPILS Antibody ARTS 1 Antibody ARTS-1 Antibody ARTS1 Antibody Endoplasmic reticulum aminopeptidase 1 Antibody Endoplasmic reticulum aminopeptidase associated with antigen processing Antibody ERAAP Antibody ERAAP1 Antibody ERAP 1 Antibody Erap1 Antibody ERAP1_HUMAN Antibody KIAA0525 Antibody kiaa0525 protein Antibody PILS AP Antibody PILS-AP Antibody PILSA Antibody PILSAP Antibody Puromycin insensitive leucyl specific aminopeptidase Antibody Puromycin-insensitive leucyl-specific aminopeptidase Antibody Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator Antibody type 1 tumor necrosis factor receptors shedding aminopeptidase regulator Antibody VEGF-induced aminopeptidase Antibody
Information:	Target information shown above is from the UniProt Consortium.