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Anti-ERAB (E135) Antibody

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规格：50µl

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Anti-ERAB (E135) Antibody

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Overview

Name:	Anti-ERAB (E135) Antibody See all ERAB primary antibodies
Description:	Rabbit polyclonal antibody to ERAB (E135)
Specificity:	ERAB (E135) pAb detects endogenous levels of ERAB protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 102-150 of Human ERAB.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 27 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
Tissue Specificity:	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.
Involvement in Disease:	2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: A disorder that leads to neurological abnormalities, including psychomotor retardation and, in virtually all patients, loss of mental and motor skills. Mental retardation, X-linked, syndromic, 10: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXS10 patients manifest mild mental retardation, choreoathetosis and abnormal behavior. Mental retardation, X-linked 17: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Sequence Similarities:	Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Cellular Location:	Mitochondrion.
Database Links:	Entrez Gene: 3028?Human Entrez Gene: 15108?Mouse Entrez Gene: 63864?Rat Omim: 300256?Human SwissProt: Q99714?Human SwissProt: O08756?Mouse SwissProt: O70351?Rat Unigene: 171280?Human Unigene: 6994?Mouse Unigene: 2700?Rat
Synonyms:	17 beta hydroxysteroid dehydrogenase 10 Antibody 17 beta hydroxysteroid dehydrogenase type 10 Antibody 17-beta-HSD 10 Antibody 17-beta-hydroxysteroid dehydrogenase 10 Antibody 17b HSD10 Antibody 3 hydroxy 2 methylbutyryl CoA dehydrogenase Antibody 3 hydroxyacyl CoA dehydrogenase type 2 Antibody 3 hydroxyacyl CoA dehydrogenase type II Antibody 3-hydroxy-2-methylbutyryl-CoA dehydrogenase Antibody 3-hydroxyacyl-CoA dehydrogenase type II Antibody 3-hydroxyacyl-CoA dehydrogenase type-2 Antibody AB binding alcohol dehydrogenase Antibody ABAD Antibody Ads9 Antibody Amyloid beta binding polypeptide Antibody Amyloid beta peptide binding alcohol dehydrogenase Antibody Amyloid beta peptide binding protein Antibody CAMR Antibody DUPXp11.22 Antibody Endoplasmic Reticulum Amyloid Binding Protein Antibody Endoplasmic reticulum associated amyloid beta peptide binding protein Antibody Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Antibody ER associated amyloid beta-binding protein Antibody ERAB Antibody HADH 2 Antibody HADH2 Antibody HCD 2 Antibody HCD2 Antibody HCD2_HUMAN Antibody Hsd17b10 Antibody Hydroxyacyl CoA Dehydrogenase type II Antibody Hydroxyacyl Coenzyme A dehydrogenase type II Antibody Hydroxysteroid (17 beta) dehydrogenase 10 Antibody Mental retardation X linked syndromic 11 Antibody MHBD Antibody Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase Antibody Mitochondrial ribonuclease P protein 2 Antibody Mitochondrial RNase P protein 2 Antibody MRPP2 Antibody MRX17 Antibody SCHAD Antibody SDR5C1 Antibody Short chain dehydrogenase/reductase family 5C member 1 Antibody Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 Antibody Short chain type dehydrogenase/reductase XH98G2 Antibody Short-chain type dehydrogenase/reductase XH98G2 Antibody Type 10 17b HSD Antibody Type 10 17beta hydroxysteroid dehydrogenase Antibody Type II HADH Antibody XH98G2 Antibody
Information:	Target information shown above is from the UniProt Consortium.