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Anti-Epsin 1 Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-Epsin 1 Antibody

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Overview

Name:	Anti-Epsin 1 Antibody See all Epsin 1 primary antibodies
Description:	Rabbit polyclonal antibody to Epsin 1
Specificity:	Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein.
Applications:	WB, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the Internal region of human Epsin 1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20˚C / 1 year

Target

Function:	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Sequence Similarities:	Belongs to the epsin family.
Post-Translational Modification:	Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
Cellular Location:	Cytoplasm. Cell membrane. Nucleus. Membrane > Clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
Database Links:	Entrez Gene: 29924 Human Entrez Gene: 13854 Mouse Entrez Gene: 117277 Rat Omim: 607262 Human SwissProt: Q9Y6I3 Human SwissProt: Q80VP1 Mouse SwissProt: O88339 Rat Unigene: 279953 Human Unigene: 3091 Mouse Unigene: 30007 Rat
Synonyms:	EH domain binding mitotic phosphoprotein Antibody EH domain-binding mitotic phosphoprotein Antibody EPN 1 Antibody Epn1 Antibody EPN1_HUMAN Antibody EPS 15 interacting protein 1 Antibody EPS-15-interacting protein 1 Antibody Epsin 1 Antibody Epsin-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.