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Anti-Eps15 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Eps15 Antibody

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Overview

Name:	Anti-Eps15 Antibody See all Eps15 primary antibodies
Description:	Rabbit polyclonal antibody to Eps15
Specificity:	The antibody detects endogenous levels of total Eps15 protein.
Applications:	WB
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region within amino acids 832 and 896 of Eps15.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by antigen-affinity chromatography.
Concentration:	0.83mg / ml
Formulation:	Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C

Target

Function:	Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Tissue Specificity:	Ubiquitously expressed.
Post-Translational Modification:	Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.
Cellular Location:	Cytoplasm. Cell membrane. Membrane > Clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.
Database Links:	Entrez Gene: 2060 Human Entrez Gene: 13858 Mouse Omim: 600051 Human SwissProt: P42566 Human SwissProt: P42567 Mouse Unigene: 83722 Human Unigene: 318250 Mouse
Synonyms:	AF 1P Antibody AF 1p protein Antibody AF1P Antibody ALL1 fused gene from chromosome 1 Antibody Epidermal growth factor receptor pathway substrate 15 Antibody Epidermal growth factor receptor substrate 15 Antibody EPS 15 Antibody EPS15 Antibody MLLT 5 Antibody MLLT5 Antibody Protein Eps 15 Antibody Protein Eps15 Antibody
Information:	Target information shown above is from the UniProt Consortium.