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Anti-ENPP2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ENPP2 Antibody

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Overview

Name:	Anti-ENPP2 Antibody See all ENPP2 primary antibodies
Description:	Rabbit polyclonal antibody to ENPP2
Specificity:	The antibody detects endogenous level of total ENPP2 polyclonal antibody.
Applications:	IHC
Reactivity:	Human
Immunogen:	Recombinant human Ectonucleotide pyrophosphatase / phosphodiesterase family member 2 protein (564-863aa)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen Affinity Purified
Concentration:	1.0mg / mL
Formulation:	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:	Store at -20?C

Target

Function:	Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Tissue Specificity:	Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.
Sequence Similarities:	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Post-Translational Modification:	N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity.
Cellular Location:	Secreted. Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Database Links:	Entrez Gene: 5168?Human Omim: 601060?Human SwissProt: Q13822?Human Unigene: 190977?Human
Synonyms:	ATX Antibody ATX X Antibody Autotaxin Antibody Autotaxin t Antibody E NPP 2 Antibody E-NPP 2 Antibody Ectonucleotide pyrophosphatase/phosphodiesterase 2 Antibody Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Antibody ENPP2 Antibody ENPP2_HUMAN Antibody Extracellular lysophospholipase D Antibody FLJ26803 Antibody LysoPLD Antibody NPP2 Antibody PD IALPHA Antibody PDNP2 Antibody Phosphodiesterase I alpha Antibody Phosphodiesterase I/nucleotide pyrophosphatase 2 Antibody Plasma lysophospholipase D Antibody
Information:	Target information shown above is from the UniProt Consortium.