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Anti-ELL Antibody

品牌：Antibodies

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规格：100µl

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Anti-ELL Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-ELL Antibody See all ELL primary antibodies
Description:	Rabbit polyclonal antibody to ELL.
Applications:	WB
Dilutions:	WB: 1:200 - 1:500.
Reactivity:	Human, Mouse
Immunogen:	A synthetic peptide of human ELL.
Protein Length:	621
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Tissue Specificity:	Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
Sequence Similarities:	Belongs to the ELL/occludin family.
Cellular Location:	Nucleus. Nucleus speckle. Nucleus > Cajal body. Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes(PubMed:23932780).
Database Links:	Entrez Gene: 8178 Human Omim: 600284 Human SwissProt: P55199 Human Unigene: 515260 Human
Synonyms:	eleven nineteen lysine rich leukemia gene Antibody Eleven-nineteen lysine-rich leukemia protein Antibody ELL Antibody ELL1 Antibody elongation factor RNA polymerase II Antibody Men Antibody RNA polymerase II elongation factor Antibody
Information:	Target information shown above is from the UniProt Consortium.