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Anti-ELF4 Antibody

品牌：Antibodies

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规格：50µl

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Anti-ELF4 Antibody

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Overview

Name:	Anti-ELF4 Antibody See all ELF4 primary antibodies
Description:	Rabbit polyclonal antibody to ELF4.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human ELF4.
Protein Length:	663
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
Tissue Specificity:	Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.
Sequence Similarities:	Belongs to the ETS family.
Cellular Location:	Nucleus > PML body. Accumulation into PML nuclear bodies is mediated by PML.
Database Links:	Entrez Gene: 2000?Human SwissProt: Q99607?Human Unigene: 271940?Human
Synonyms:	E74-like factor 4 Antibody ELF4 Antibody Elf4/MEF Antibody ELF4_HUMAN Antibody ELFR Antibody ETS-related transcription factor Elf-4 Antibody ETS-related transcription factor Elf4 Antibody MEF Antibody Myeloid Elf-1-like factor Antibody Myeloid Elf1-like factor Antibody
Information:	Target information shown above is from the UniProt Consortium.