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Anti-ELAC2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ELAC2 Antibody

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Overview

Name:	Anti-ELAC2 Antibody See all ELAC2 primary antibodies
Description:	Rabbit polyclonal antibody to ELAC2
Specificity:	The antibody detects endogenous levels of total ELAC2 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human elaC ribonuclease Z 2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Tissue Specificity:	Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
Involvement in Disease:	Prostate cancer, hereditary, 2: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Combined oxidative phosphorylation deficiency 17: An autosomal recessive disorder of mitochondrial dysfunction characterized by onset of severe hypertrophic cardiomyopathy in the first year of life. Other features include hypotonia, poor growth, lactic acidosis, and failure to thrive. The disorder may be fatal in early childhood.
Sequence Similarities:	Belongs to the RNase Z family.
Cellular Location:	Mitochondrion. Nucleus. Mainly mitochondrial.
Database Links:	Entrez Gene: 60528?Human Omim: 605367?Human SwissProt: Q9BQ52?Human Unigene: 434232?Human
Synonyms:	COXPD17 Antibody elaC homolog 2 (E. coli) Antibody ElaC homolog protein 2 Antibody elaC ribonuclease Z 2 Antibody elaC, E. coli, homolog of, 2 Antibody ELAC2 Antibody ELC2 Antibody FLJ10530 Antibody FLJ36693 Antibody FLJ42848 Antibody Heredity prostate cancer protein 2 Antibody HPC2 Antibody putative prostate cancer susceptibility protein HPC2/ELAC2 Antibody Ribonuclease Z 2 Antibody Ribonuclease Z, long form Antibody Ribonuclease Z2 Antibody RNase Z 2 Antibody RNase Z2 Antibody RNase ZL Antibody RNZ2_HUMAN Antibody tRNA 3 endonuclease 2 Antibody tRNase Z (long form) Antibody tRNase Z 2 Antibody tRNase Z2 Antibody Zinc phosphodiesterase ELAC protein 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.