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Anti-eIF4B (phospho-S422) Antibody

品牌：Antibodies

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规格：50µl

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Anti-eIF4B (phospho-S422) Antibody

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Name:	Anti-eIF4B (phospho-S422) Antibody See all eIF4B primary antibodies
Description:	Rabbit polyclonal antibody to eIF4B (phospho-S422)
Specificity:	p-eIF4B (S422) pAb detects endogenous levels of eIF4B protein only when phosphorylated at Ser422
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human eIF4B around the phosphorylation site of Serine 422.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 80 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Post-Translational Modification:	Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.
Database Links:	Entrez Gene: 1975?Human Entrez Gene: 75705?Mouse Entrez Gene: 300253?Rat Omim: 603928?Human SwissProt: P23588?Human SwissProt: Q8BGD9?Mouse Unigene: 648394?Human Unigene: 702041?Human Unigene: 290022?Mouse Unigene: 391795?Mouse Unigene: 95954?Rat
Synonyms:	2310046H11Rik Antibody AL024095 Antibody C85189 Antibody EIF 4B Antibody eIF-4B Antibody eIF4B Antibody Eukaryotic initiation factor 4B Antibody Eukaryotic translation initiation factor 4B Antibody IF4B_HUMAN Antibody PRO1843 Antibody
Information:	Target information shown above is from the UniProt Consortium.