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Anti-eIF3K Antibody

品牌：Antibodies

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规格：100µl

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Anti-eIF3K Antibody

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Overview

Name:	Anti-eIF3K Antibody See all eIF3K primary antibodies
Description:	Rabbit polyclonal antibody to eIF3K
Applications:	WB, IF
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 133 (Q9UBQ5) of EIF3K
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified by Protein A.
Formulation:	Supplied in 1XPBS, 1%BSA, 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.

Target

Function:	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Tissue Specificity:	Ubiquitous, with the highest levels of expression in brain, testis and kidney.
Sequence Similarities:	Belongs to the eIF-3 subunit K family.
Cellular Location:	Nucleus. Cytoplasm.
Database Links:	Entrez Gene: 27335 Human Omim: 609596 Human SwissProt: Q9UBQ5 Human Unigene: 314359 Human
Synonyms:	ARG134 Antibody eIF 3 p25 Antibody eIF 3 p28 Antibody eIF-3 p25 Antibody eIF-3 p28 Antibody EIF3-p28 Antibody eIF3K Antibody EIF3K_HUMAN Antibody EIF3S12 Antibody Eukaryotic translation initiation factor 3 subunit 12 Antibody Eukaryotic translation initiation factor 3 subunit K Antibody HSPC029 Antibody M9 Antibody MSTP001 Antibody Muscle specific gene M9 protein Antibody Muscle-specific gene M9 protein Antibody PLAC 24 Antibody PLAC-24 Antibody PLAC24 Antibody PRO1474 Antibody PTD001 Antibody
Information:	Target information shown above is from the UniProt Consortium.