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Anti-EIF3I Antibody

品牌：Antibodies

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规格：100µl

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Anti-EIF3I Antibody

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Overview

Name:	Anti-EIF3I Antibody See all EIF3I primary antibodies
Description:	Rabbit polyclonal antibody to EIF3I
Specificity:	The antibody detects endogenous levels of total EIF3I protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein of human EIF3I
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Sequence Similarities:	Belongs to the eIF-3 subunit I family.
Post-Translational Modification:	Phosphorylated by TGF-beta type II receptor.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 8668?Human Omim: 603911?Human SwissProt: Q13347?Human Unigene: 530096?Human
Synonyms:	eIF-3-beta Antibody eIF3 beta Antibody eIF3 p36 Antibody eIF3-beta Antibody eIF3-p36 Antibody eIF3i Antibody EIF3I_HUMAN Antibody EIF3S2 Antibody EIF3S2, formerly Antibody Eukaryotic translation initiation factor 3 subunit 2 Antibody Eukaryotic translation initiation factor 3 subunit 2 beta Antibody Eukaryotic translation initiation factor 3 subunit I Antibody eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD Antibody eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa Antibody eukaryotic translation initiation factor 3, subunit 2, formerly Antibody eukaryotic translation initiation factor 3, subunit I Antibody Predicted protein of HQ2242 Antibody PRO2242 Antibody TGF beta receptor interacting protein 1 Antibody TGF-beta receptor-interacting protein 1 Antibody TGFbeta receptor interacting protein 1 Antibody TGFbeta receptor-interacting protein 1 Antibody TRIP 1 Antibody TRIP-1 Antibody TRIP1 Antibody
Information:	Target information shown above is from the UniProt Consortium.