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Anti-EIF3F Antibody

品牌：Antibodies

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规格：100µl

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Anti-EIF3F Antibody

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Overview

Name:	Anti-EIF3F Antibody See all EIF3F primary antibodies
Description:	Rabbit polyclonal antibody to EIF3F
Specificity:	The antibody detects endogenous levels of total EIF3F protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Fusion protein corresponding to residues near the C terminal of human eukaryotic translation initiation factor 3, subunit F
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Sequence Similarities:	Belongs to the eIF-3 subunit F family.
Post-Translational Modification:	Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 8665?Human Entrez Gene: 66085?Mouse Omim: 603914?Human SwissProt: O00303?Human SwissProt: Q9DCH4?Mouse Unigene: 516023?Human Unigene: 182962?Mouse
Synonyms:	Deubiquitinating enzyme eIF3f Antibody eIF 3 epsilon Antibody eIF-3-epsilon Antibody eIF3 p47 Antibody eIF3 p47 subunit Antibody eIF3-epsilon Antibody eIF3-p47 Antibody EIF3F Antibody EIF3F_HUMAN Antibody EIF3S5 Antibody EIF3S5, formerly Antibody Eukaryotic translation initiation factor 3 subunit 5 Antibody Eukaryotic translation initiation factor 3 subunit 5, formerly Antibody Eukaryotic translation initiation factor 3 subunit F Antibody eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD) Antibody eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa Antibody eukaryotic translation initiation factor 3, subunit F Antibody translation initiation factor 3 47 kda subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.