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Anti-EIF3D Antibody

品牌：Antibodies

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规格：50µl

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Anti-EIF3D Antibody

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Overview

Name:	Anti-EIF3D Antibody See all EIF3D primary antibodies
Description:	Rabbit polyclonal antibody to EIF3D
Specificity:	The antibody detects endogenous levels of total EIF3D protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human EIF3D.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
Sequence Similarities:	Belongs to the eIF-3 subunit D family.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 8664?Human Entrez Gene: 55944?Mouse Omim: 603915?Human SwissProt: O15371?Human SwissProt: O70194?Mouse Unigene: 55682?Human Unigene: 3955?Mouse Unigene: 475286?Mouse
Synonyms:	eIF 3 zeta Antibody eIF-3-zeta Antibody eIF3 p66 Antibody eIF3 zeta Antibody EIF3D Antibody EIF3D_HUMAN Antibody eIF3p66 Antibody EIF3S7 Antibody Eukaryotic translation initiation factor 3 subunit 7 Antibody Eukaryotic translation initiation factor 3 subunit 7 zeta 66/67kDa Antibody Eukaryotic translation initiation factor 3 subunit D Antibody MGC126526 Antibody MGC17258 Antibody OTTHUMP00000197900 Antibody OTTHUMP00000197901 Antibody Translation initiation factor eIF3 p66 subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.