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Anti-EIF3A Antibody

品牌：Antibodies

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规格：50µl

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Anti-EIF3A Antibody

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Overview

Name:	Anti-EIF3A Antibody See all EIF3A primary antibodies
Description:	Rabbit polyclonal antibody to EIF3A.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:1000, IHC: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EIF3A.
Protein Length:	1382
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
Sequence Similarities:	Belongs to the eIF-3 subunit A family.
Post-Translational Modification:	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 8661?Human Entrez Gene: 13669?Mouse Entrez Gene: 292148?Rat Omim: 602039?Human SwissProt: Q14152?Human SwissProt: P23116?Mouse SwissProt: Q1JU68?Rat Unigene: 523299?Human Unigene: 713331?Human Unigene: 2238?Mouse Unigene: 482533?Mouse Unigene: 1644?Rat
Synonyms:	centrosomin homolog Antibody cytoplasmic protein p167 Antibody eIF 3 theta Antibody eIF-3-theta Antibody EIF3 Antibody eIF3 p167 Antibody eIF3 p170 Antibody eIF3 p180 Antibody EIF3 p180 subunit Antibody eIF3 p185 Antibody eIF3 theta Antibody eIF3A Antibody EIF3A_HUMAN Antibody EIF3S10 Antibody Eukaryotic translation initiation factor 3 subunit 10 Antibody eukaryotic translation initiation factor 3 subunit 10 (theta 150 170kD) Antibody eukaryotic translation initiation factor 3 subunit 10 (theta 170kD) Antibody eukaryotic translation initiation factor 3 subunit 10 170kDa Antibody eukaryotic translation initiation factor 3 subunit 10 theta 150 170kDa Antibody Eukaryotic translation initiation factor 3 subunit A Antibody OTTHUMP00000020589 Antibody P167 Antibody p180 Antibody p185 Antibody TIF32 Antibody
Information:	Target information shown above is from the UniProt Consortium.