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Anti-eIF2α (2E4) Antibody

品牌：Antibodies

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规格：50µl

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Anti-eIF2α (2E4) Antibody

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Name:	Anti-eIF2α (2E4) Antibody See all eIF2α primary antibodies
Description:	Mouse monoclonal antibody to eIF2α (2E4)
Specificity:	This antibody detects endogenous levels of eIF2α and does not cross-react with related proteins.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Purified recombinant human eIF2α protein fragments expressed in E.coli.
Host:	Mouse
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	Predicted band size:38KDa Observed band size:38KDa
Purity:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Function:	Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Sequence Similarities:	Belongs to the eIF-2-alpha family.
Post-Translational Modification:	Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation (PubMed:15207627, PubMed:18032499). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).
Cellular Location:	Cytoplasmic granule. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity).