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Anti-EGFR (phospho-T669) Antibody

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规格：50µl

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Anti-EGFR (phospho-T669) Antibody

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Overview

Name:	Anti-EGFR (phospho-T669) Antibody See all EGFR primary antibodies
Description:	Rabbit polyclonal antibody to EGFR (phospho-T669)
Specificity:	p-EGFR (T669) pAb detects endogenous levels of EGFR protein only when phosphorylated at Thr669 (removal of the signal peptide).
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human EGFR around the phosphorylation site of Threonine 669.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 175 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
Tissue Specificity:	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Involvement in Disease:	Lung cancer: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Inflammatory skin and bowel disease, neonatal, 2: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification:	Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.
Cellular Location:	Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus membrane. Endosome. Endosome membrane. Nucleus. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).
Database Links:	Entrez Gene: 1956?Human Entrez Gene: 13649?Mouse Entrez Gene: 24329?Rat Omim: 131550?Human SwissProt: P00533?Human SwissProt: Q01279?Mouse Unigene: 488293?Human Unigene: 605083?Human Unigene: 420648?Mouse Unigene: 439882?Mouse Unigene: 8534?Mouse Unigene: 37227?Rat
Synonyms:	9030024J15Rik Antibody AI552599 Antibody Avian erythroblastic leukemia viral (v erb b) oncogene homolog Antibody Avian erythroblastic leukemia viral (verbb) oncogene homolog Antibody Cell growth inhibiting protein 40 Antibody Cell proliferation inducing protein 61 Antibody EGF R Antibody EGFR Antibody EGFR_HUMAN Antibody Epidermal growth factor receptor Antibody Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) Antibody Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) Antibody erb-b2 receptor tyrosine kinase 1 Antibody Erbb Antibody erbb 1 Antibody Erbb1 Antibody Errp Antibody Erythroblastic leukemia viral (v erb-b) oncogene homolog Antibody HER1 Antibody mENA Antibody NISBD2 Antibody Oncogen ERBB Antibody Oncogene ERBB Antibody OTTMUSP00000005385 Antibody OTTMUSP00000005386 Antibody PIG61 Antibody Proto oncogene c ErbB 1 Antibody Proto-oncogene c-ErbB-1 Antibody Receptor tyrosine protein kinase ErbB 1 Antibody Receptor tyrosine protein kinase ErbB1 Antibody Receptor tyrosine-protein kinase ErbB-1 Antibody RP23-295E4.1 Antibody SA7 Antibody Species antigen 7 Antibody Urogastrone Antibody v-erb-b Avian erythroblastic leukemia viral oncogen homolog Antibody wa2 Antibody Wa5 Antibody
Information:	Target information shown above is from the UniProt Consortium.