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Anti-Dyrk1A Antibody

品牌：Antibodies

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规格：50µl

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Anti-Dyrk1A Antibody

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Overview

Name:	Anti-Dyrk1A Antibody See all Dyrk1A primary antibodies
Description:	Rabbit polyclonal antibody to Dyrk1A
Specificity:	Dyrk1A Polyclonal Antibody detects endogenous levels of Dyrk1A protein.
Applications:	WB, IHC, IF, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the N-terminal region of human Dyrk1A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Tissue Specificity:	Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Involvement in Disease:	Mental retardation, autosomal dominant 7: A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Post-Translational Modification:	Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).
Cellular Location:	Nucleus. Nucleus speckle.
Database Links:	Entrez Gene: 1859?Human Entrez Gene: 13548?Mouse Entrez Gene: 25255?Rat Omim: 600855?Human SwissProt: Q13627?Human SwissProt: Q61214?Mouse SwissProt: Q63470?Rat Unigene: 368240?Human Unigene: 310973?Mouse Unigene: 9354?Rat
Synonyms:	Dual specificity tyrosine phosphorylation regulated kinase Antibody Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A Antibody Dual specificity tyrosine phosphorylation regulated kinase 1 Antibody Dual specificity tyrosine phosphorylation regulated kinase 1A Antibody Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody Dual specificity YAK 1 related kinase Antibody Dual specificity YAK1 related kinase Antibody Dual specificity YAK1-related kinase Antibody DYR1A_HUMAN Antibody DYRK Antibody DYRK 1 Antibody DYRK 1A Antibody DYRK1 Antibody DYRK1A Antibody DYRKA Antibody hMNB Antibody HP 86 Antibody HP86 Antibody Minibrain (Drosophila) homolog Antibody Minibrain homolog Antibody Minibrain, Drosophila, homolog of Antibody MNB Antibody MNB protein kinase Antibody Mnb protein kinase homolog hp86 Antibody MNB protein kinase, Serine/threonine-specific Antibody MNB/DYRK protein kinase Antibody MNBH Antibody MRD7 Antibody OTTHUMP00000109090 Antibody OTTHUMP00000109091 Antibody OTTHUMP00000109094 Antibody OTTHUMP00000174799 Antibody Protein kinase minibrain homolog Antibody Serine/threonine kinase MNB Antibody
Information:	Target information shown above is from the UniProt Consortium.