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Anti-DUSP6 (L76) Antibody

品牌：Antibodies

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规格：50µl

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Anti-DUSP6 (L76) Antibody

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Overview

Name:	Anti-DUSP6 (L76) Antibody See all DUSP6 primary antibodies
Description:	Rabbit polyclonal antibody to DUSP6 (L76)
Specificity:	DUSP6 (L76) pAb detects endogenous levels of DUSP6 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 43-98 of Human DUSP6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).
Involvement in Disease:	Hypogonadotropic hypogonadism 19 with or without anosmia: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Sequence Similarities:	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 1848?Human Entrez Gene: 67603?Mouse Entrez Gene: 116663?Rat Omim: 602748?Human SwissProt: Q16828?Human SwissProt: Q9DBB1?Mouse SwissProt: Q64346?Rat Unigene: 298654?Human Unigene: 718640?Human Unigene: 1791?Mouse Unigene: 4313?Rat
Synonyms:	Dual specificity phosphatase 6 Antibody Dual specificity phosphatase 6 isoform a Antibody Dual specificity protein phosphatase 6 Antibody Dual specificity protein phosphatase PYST1 Antibody DUS6_HUMAN Antibody DUSP 6 Antibody DUSP 6a Antibody DUSP6 Antibody DUSP6a Antibody HH19 Antibody MAP kinase phosphatase 3 Antibody Mitogen activated protein kinase phosphatase 3 Antibody Mitogen-activated protein kinase phosphatase 3 Antibody MKP 3 Antibody MKP-3 Antibody MKP3 Antibody PYST 1 Antibody PYST1 Antibody Serine/threonine specific protein phosphatase Antibody
Information:	Target information shown above is from the UniProt Consortium.