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Anti-DR4 (D430) Antibody

品牌：Antibodies

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规格：50µl

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Anti-DR4 (D430) Antibody

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Name:	Anti-DR4 (D430) Antibody See all DR4 primary antibodies
Description:	Rabbit polyclonal antibody to DR4 (D430)
Specificity:	DR4 (D430) pAb detects endogenous levels of DR4 protein.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 401-450 of Human DR4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 50 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Tissue Specificity:	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 8797 Human Omim: 603611 Human SwissProt: O00220 Human Unigene: 213467 Human Unigene: 591834 Human
Synonyms:	Apo2 Antibody CD261 Antibody Cytotoxic TRAIL receptor Antibody Death receptor 4 Antibody DR4 Antibody NF related apoptosis-inducing ligand receptor 1 Antibody TNF receptor superfamily member 10a Antibody TNF-related apoptosis-inducing ligand receptor 1 Antibody TNFRSF10A Antibody TR10A_HUMAN Antibody TRAIL receptor 1 Antibody TRAIL-R1 Antibody TRAILR 1 Antibody TRAILR1 Antibody Tumor necrosis factor receptor superfamily member 10A Antibody Tumor necrosis factor receptor superfamily member 10a variant 2 Antibody Tumor necrosis factor receptor superfamily, member 10a Antibody
Information:	Target information shown above is from the UniProt Consortium.