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Anti-Doublecortin (K292) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Doublecortin (K292) Antibody

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Overview

Name:	Anti-Doublecortin (K292) Antibody See all Doublecortin primary antibodies
Description:	Rabbit polyclonal antibody to Doublecortin (K292)
Specificity:	Doublecortin (K292) pAb detects endogenous levels of Doublecortin protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 271-320 of Human Doublecortin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 45 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Tissue Specificity:	Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the *****, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
Involvement in Disease:	Lissencephaly, X-linked 1: A classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'. Subcortical band heterotopia X-linked: SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.
Post-Translational Modification:	Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity).
Cellular Location:	Cytoplasm. Cell projection. Localizes at neurite tips.
Database Links:	Entrez Gene: 1641?Human Entrez Gene: 13193?Mouse Entrez Gene: 84394?Rat Omim: 300121?Human SwissProt: O43602?Human SwissProt: O88809?Mouse SwissProt: Q9ESI7?Rat Unigene: 34780?Human Unigene: 12871?Mouse Unigene: 121471?Rat
Synonyms:	DBCN Antibody Dbct Antibody DC Antibody DCX Antibody DCX_HUMAN Antibody Doublecortex Antibody Doublecortin Antibody Doublin Antibody FLJ51296 Antibody Lis X Antibody Lis-X Antibody Lissencephalin X Antibody Lissencephalin-X Antibody Lissencephaly X linked Antibody Lissencephaly X linked doublecortin Antibody LISX Antibody Neuronal migration protein doublecortin Antibody OTTHUMP00000023859 Antibody OTTHUMP00000023860 Antibody OTTHUMP00000216315 Antibody OTTHUMP00000216316 Antibody SCLH Antibody XLIS Antibody
Information:	Target information shown above is from the UniProt Consortium.